Cardiovascular Issues in Tyrosine Kinase Inhibitors Treatments for Chronic Myeloid Leukemia: A Review

Cardiovascular Issues in Tyrosine Kinase Inhibitors Treatments for Chronic Myeloid Leukemia: A Review

Chronic myeloid leukemia (CML) is a myeloproliferative neoplasm driven by a fusion gene, encoding for the chimeric protein BCR-ABL, with constitutive tyrosine kinase activity. The use of tyrosine kinase inhibitors (TKIs) has drastically improved survival, but there are significant concerns about car...

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Bibliographic Details
Main Authors: Marco Santoro, Salvatrice Mancuso, Vincenzo Accurso, Daniela Di Lisi, Giuseppina Novo, Sergio Siragusa
Format: Article
Language:English
Published: Frontiers Media S.A. 2021-07-01
Series:Frontiers in Physiology
Subjects:
cardiovascular events
chronic myelocytic leukemia
cardiovascular risk
cardio-oncology
tyrosine kinase inhibitions therapy
Online Access:https://www.frontiersin.org/articles/10.3389/fphys.2021.675811/full

Internet

https://www.frontiersin.org/articles/10.3389/fphys.2021.675811/full

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