E47 Governs the MYC-CDKN1B/p27KIP1-RB Network to Growth Arrest PDA Cells Independent of CDKN2A/p16INK4A and Wild-Type p53Summary

E47 Governs the MYC-CDKN1B/p27KIP1-RB Network to Growth Arrest PDA Cells Independent of CDKN2A/p16INK4A and Wild-Type p53Summary

Background & Aims: Oncogenic mutations in KRAS, coupled with inactivation of p53, CDKN2A/p16INK4A, and SMAD4, drive progression of pancreatic ductal adenocarcinoma (PDA). Overexpression of MYC and deregulation of retinoblastoma (RB) further promote cell proliferation and make identifying a means...

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Bibliographic Details
Main Authors: Kathleen M. Scully, Reyhaneh Lahmy, Lia Signaevskaia, Roman Sasik, Rachel Medal, Heejung Kim, Randall French, Brian James, Yifan Wu, Andrew M. Lowy, Pamela Itkin-Ansari
Format: Article
Language:English
Published: Elsevier 2018-01-01
Series:Cellular and Molecular Gastroenterology and Hepatology
Online Access:http://www.sciencedirect.com/science/article/pii/S2352345X18300717

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http://www.sciencedirect.com/science/article/pii/S2352345X18300717

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