Polygenic Risk Score for Early Prediction of Sepsis Risk in the Polytrauma Screening Cohort

Polygenic Risk Score for Early Prediction of Sepsis Risk in the Polytrauma Screening Cohort

BackgroundIncreasing genetic variants associated with sepsis have been identified by candidate-gene and genome-wide association studies, but single variants conferred minimal alterations in risk prediction. Our aim is to evaluate whether a weighted genetic risk score (wGRS) that aggregates informati...

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Bibliographic Details
Main Authors: Hongxiang Lu, Dalin Wen, Jianhui Sun, Juan Du, Liang Qiao, Huacai Zhang, Ling Zeng, Lianyang Zhang, Jianxin Jiang, Anqiang Zhang
Format: Article
Language:English
Published: Frontiers Media S.A. 2020-11-01
Series:Frontiers in Genetics
Subjects:
trauma
sepsis
prediction
genetic variants
weighted genetic risk score
Online Access:https://www.frontiersin.org/articles/10.3389/fgene.2020.545564/full

Internet

https://www.frontiersin.org/articles/10.3389/fgene.2020.545564/full

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