Finerenone Attenuates Endothelial Dysfunction and Albuminuria in a Chronic Kidney Disease Model by a Reduction in Oxidative Stress

Finerenone Attenuates Endothelial Dysfunction and Albuminuria in a Chronic Kidney Disease Model by a Reduction in Oxidative Stress

Albuminuria is an early marker of renovascular damage associated to an increase in oxidative stress. The Munich Wistar Frömter (MWF) rat is a model of chronic kidney disease (CKD), which exhibits endothelial dysfunction associated to low nitric oxide availability. We hypothesize that the new highly...

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Bibliographic Details
Main Authors: Raquel González-Blázquez, Beatriz Somoza, Marta Gil-Ortega, Miriam Martín Ramos, David Ramiro-Cortijo, Elena Vega-Martín, Angela Schulz, Luis Miguel Ruilope, Peter Kolkhof, Reinhold Kreutz, María S. Fernández-Alfonso
Format: Article
Language:English
Published: Frontiers Media S.A. 2018-10-01
Series:Frontiers in Pharmacology
Subjects:
albuminuria
finerenone
aldosterone antagonists
aorta endothelial dysfunction
oxidative stress
Online Access:https://www.frontiersin.org/article/10.3389/fphar.2018.01131/full

Internet

https://www.frontiersin.org/article/10.3389/fphar.2018.01131/full

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