Direct Nucleophilic Difluoromethylation of Aromatic Isoxazoles Activated by Electron-Withdrawing Groups Using (Difluoromethyl)trimethylsilane
The activation of aromatic diaryl isoxazoles with strong electron-withdrawing groups, such as the nitro, triflyl and the phenylsulfonyl groups, at the 4-position has enabled the first regio- and diastereoselective difluoromethylation at the 5-position of isoxazoles by nucleophilic addition using (di...
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| Format: | Article |
| Language: | English |
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ScienceOpen
2014-11-01
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| Series: | ScienceOpen Research |
| Online Access: | https://www.scienceopen.com/document?vid=aeab23b4-61ff-4936-a252-0cd98d9fddcf |