Association of NMT2 with the acyl-CoA carrier ACBD6 protects the N-myristoyltransferase reaction from palmitoyl-CoA[S]

Association of NMT2 with the acyl-CoA carrier ACBD6 protects the N-myristoyltransferase reaction from palmitoyl-CoA[S]

The covalent attachment of a 14-carbon aliphatic tail on a glycine residue of nascent translated peptide chains is catalyzed in human cells by two N-myristoyltransferase (NMT) enzymes using the rare myristoyl-CoA (C14-CoA) molecule as fatty acid donor. Although, NMT enzymes can only transfer a myris...

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Bibliographic Details
Main Authors: Eric Soupene, Joseph Kao, Daniel H. Cheng, Derek Wang, Alexander L. Greninger, Giselle M. Knudsen, Joseph L. DeRisi, Frans A. Kuypers
Format: Article
Language:English
Published: Elsevier 2016-02-01
Series:Journal of Lipid Research
Subjects:
protein acylation
membranes
phospholipids
binding protein
protein interaction
N-myristoyltransferase 2
Online Access:http://www.sciencedirect.com/science/article/pii/S002222752035464X

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http://www.sciencedirect.com/science/article/pii/S002222752035464X

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