Modulating the Mechanical Activation of TRPV4 at the Cell-Substrate Interface

Ion channels activated by mechanical inputs are important force sensing molecules in a wide array of mammalian cells and tissues. The transient receptor potential channel, TRPV4, is a polymodal, nonselective cation channel that can be activated by mechanical inputs but only if stimuli are applied di...

Full description

Bibliographic Details
Main Authors: Setareh Sianati, Lioba Schroeter, Jessica Richardson, Andy Tay, Shireen R. Lamandé, Kate Poole
Format: Article
Language:English
Published: Frontiers Media S.A. 2021-01-01
Series:Frontiers in Bioengineering and Biotechnology
Subjects:
Online Access:https://www.frontiersin.org/articles/10.3389/fbioe.2020.608951/full