Four-factor prothrombin complex concentrate to reduce allogenic blood product transfusion in patients with major trauma, the PROCOAG trial: study protocol for a randomized multicenter double-blind superiority study

Four-factor prothrombin complex concentrate to reduce allogenic blood product transfusion in patients with major trauma, the PROCOAG trial: study protocol for a randomized multicenter double-blind superiority study

Abstract Background Optimal management of severe trauma patients with active hemorrhage relies on adequate initial resuscitation. Early administration of coagulation factors improves post-traumatic coagulation disorders, and four-factor prothrombin complex concentrate (PCC) might be useful in this c...

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Bibliographic Details
Main Authors: Pierre Bouzat, Jean-Luc Bosson, Jean-Stéphane David, Bruno Riou, Jacques Duranteau, Jean-François Payen, on behalf of the PROCOAG study group
Format: Article
Language:English
Published: BMC 2021-09-01
Series:Trials
Subjects:
Acute traumatic coagulopathy
Prothrombin complex concentrate
Severe trauma
Massive transfusion
Online Access:https://doi.org/10.1186/s13063-021-05524-x

Internet

https://doi.org/10.1186/s13063-021-05524-x

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