Genome-Wide Association Study on Immunoglobulin G Glycosylation Patterns

Genome-Wide Association Study on Immunoglobulin G Glycosylation Patterns

Immunoglobulin G (IgG), a glycoprotein secreted by plasma B-cells, plays a major role in the human adaptive immune response and are associated with a wide range of diseases. Glycosylation of the Fc binding region of IgGs, responsible for the antibody’s effector function, is essential for prompting a...

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Bibliographic Details
Main Authors: Annika Wahl, Erik van den Akker, Lucija Klaric, Jerko Štambuk, Elisa Benedetti, Rosina Plomp, Genadij Razdorov, Irena Trbojević-Akmačić, Joris Deelen, Diana van Heemst, P. Eline Slagboom, Frano Vučković, Harald Grallert, Jan Krumsiek, Konstantin Strauch, Annette Peters, Thomas Meitinger, Caroline Hayward, Manfred Wuhrer, Marian Beekman, Gordan Lauc, Christian Gieger
Format: Article
Language:English
Published: Frontiers Media S.A. 2018-02-01
Series:Frontiers in Immunology
Subjects:
genome-wide association study
immunoglobulin G
glycosylation
RUNX3
LC–ESI-MS
Online Access:http://journal.frontiersin.org/article/10.3389/fimmu.2018.00277/full

Internet

http://journal.frontiersin.org/article/10.3389/fimmu.2018.00277/full

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