β-secretase 1´s Targeting Reduces Hyperphosphorilated Tau, Implying Autophagy Actors in 3xTg-AD Mice

β-secretase 1´s Targeting Reduces Hyperphosphorilated Tau, Implying Autophagy Actors in 3xTg-AD Mice

β-site APP cleaving enzyme 1 (BACE1) initiates APP cleavage, which has been reported to be an inducer of tau pathology by altering proteasome functions in Alzheimer’s disease (AD). However, the exact relationship between BACE1 and PHF (Paired Helical Filaments) formation is not clear. In this study,...

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Bibliographic Details
Main Authors: Diego ePiedrahita, John Fredy Castro-Alvarez, Ryan eBoudreau, Carlos Andrés Villegas, Kenneth eKosik, Juan Carlos eGallego-Gomez, Gloria Patricia eCardona-Gomez
Format: Article
Language:English
Published: Frontiers Media S.A. 2016-01-01
Series:Frontiers in Cellular Neuroscience
Subjects:
Autophagy
lipid rafts
Tauopathy
chaperones
Alzheimer’s disease.
β-secretase 1
Online Access:http://journal.frontiersin.org/Journal/10.3389/fncel.2015.00498/full

Internet

http://journal.frontiersin.org/Journal/10.3389/fncel.2015.00498/full

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