Combination of Alanine and Glutathione as Targeting Ligands of Nanoparticles Enhances Cargo Delivery into the Cells of the Neurovascular Unit

Combination of Alanine and Glutathione as Targeting Ligands of Nanoparticles Enhances Cargo Delivery into the Cells of the Neurovascular Unit

Inefficient drug delivery across the blood–brain barrier (BBB) and into target cells in the brain hinders the treatment of neurological diseases. One strategy to increase the brain penetration of drugs is to use vesicular nanoparticles functionalized with multiple ligands of BBB transporters as vehi...

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Bibliographic Details
Main Authors: Gergő Porkoláb, Mária Mészáros, András Tóth, Anikó Szecskó, András Harazin, Zsolt Szegletes, Györgyi Ferenc, András Blastyák, Lajos Mátés, Gábor Rákhely, Mária A. Deli, Szilvia Veszelka
Format: Article
Language:English
Published: MDPI AG 2020-07-01
Series:Pharmaceutics
Subjects:
blood–brain barrier
neurovascular unit
alanine
glutathione
nanoparticle
niosome
Online Access:https://www.mdpi.com/1999-4923/12/7/635

Internet

https://www.mdpi.com/1999-4923/12/7/635

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