MD2 activation by direct AGE interaction drives inflammatory diabetic cardiomyopathy

MD2 activation by direct AGE interaction drives inflammatory diabetic cardiomyopathy

The mechanisms underlying cardiac inflammation in diabetic cardiomyopathy are incompletely understood. Here the authors show that advanced glycation end products bind to the TLR4 co-receptor MD2 initiating pro-inflammatory pathways.

Bibliographic Details
Main Authors: Yi Wang, Wu Luo, Jibo Han, Zia A. Khan, Qilu Fang, Yiyi Jin, Xuemei Chen, Yali Zhang, Meihong Wang, Jianchang Qian, Weijian Huang, Hazel Lum, Gaojun Wu, Guang Liang
Format: Article
Language:English
Published: Nature Publishing Group 2020-05-01
Series:Nature Communications
Online Access:https://doi.org/10.1038/s41467-020-15978-3

Internet

https://doi.org/10.1038/s41467-020-15978-3

Similar Items