Hair Cell Transduction Efficiency of Single- and Dual-AAV Serotypes in Adult Murine Cochleae

Hair Cell Transduction Efficiency of Single- and Dual-AAV Serotypes in Adult Murine Cochleae

Gene delivery is a key component for the treatment of genetic hearing loss. To date, a myriad of adeno-associated virus (AAV) serotypes and surgical approaches have been employed to deliver transgenes to cochlear hair cells, but the efficacy of dual transduction remains unclear. Herein, we investiga...

Full description

Bibliographic Details
Main Authors: Ryotaro Omichi, Hidekane Yoshimura, Seiji B. Shibata, Luk H. Vandenberghe, Richard J.H. Smith
Format: Article
Language:English
Published: Elsevier 2020-06-01
Series:Molecular Therapy: Methods & Clinical Development
Subjects:
gene therapy
hearing loss
deafness
adeno-associated virus
viral vectors
tropism
Online Access:http://www.sciencedirect.com/science/article/pii/S2329050120300942

Internet

http://www.sciencedirect.com/science/article/pii/S2329050120300942

Similar Items