Targeting Death Receptor TRAIL-R2 by Chalcones for TRAIL-Induced Apoptosis in Cancer Cells

Targeting Death Receptor TRAIL-R2 by Chalcones for TRAIL-Induced Apoptosis in Cancer Cells

Tumor necrosis factor-related apoptosis-inducing ligand (TRAIL) induces apoptosis in cancer cells without toxicity to normal cells. TRAIL binds to death receptors, TRAIL-R1 (DR4) and TRAIL-R2 (DR5) expressed on cancer cell surface and activates apoptotic pathways. Endogenous TRAIL plays an important...

Full description

Bibliographic Details
Main Authors: Małgorzata Ksek, Zenon P. Czuba, Wojciech Król, Ewelina Szliszka, Dagmara Jaworska
Format: Article
Language:English
Published: MDPI AG 2012-11-01
Series:International Journal of Molecular Sciences
Subjects:
TRAIL
chalcones
apoptosis
death receptors
cancer cells
chemoprevention
Online Access:http://www.mdpi.com/1422-0067/13/11/15343

Internet

http://www.mdpi.com/1422-0067/13/11/15343

Similar Items