Synthesis and Biological Evaluation of Novel Urea- and Guanidine-Based Derivatives for the Treatment of Obesity-Related Hepatic Steatosis

Synthesis and Biological Evaluation of Novel Urea- and Guanidine-Based Derivatives for the Treatment of Obesity-Related Hepatic Steatosis

Leptin, the product of the obese gene, is an adipocyte-secreted protein hormone playing a key role in the progression of obesity and hepatic steatosis. In this study, 28 novel (thio)urea and guanidine-based analogues have been synthesized and N-(1-(4-(3-(2-chloroethyl)ureido)benzyl)piperidin-4-yl)-...

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Bibliographic Details
Main Authors: Xiaolin Liang, Heying Pei, Liang Ma, Yan Ran, Jinying Chen, Guangcheng Wang, Lijuan Chen
Format: Article
Language:English
Published: MDPI AG 2014-05-01
Series:Molecules
Subjects:
leptin
hepatic steatosis
urea and guanidine-based
diet-induced obesity
Online Access:http://www.mdpi.com/1420-3049/19/5/6163

Internet

http://www.mdpi.com/1420-3049/19/5/6163

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