Anticoagulants Influence the Performance of In Vitro Assays Intended for Characterization of Nanotechnology-Based Formulations

Anticoagulants Influence the Performance of In Vitro Assays Intended for Characterization of Nanotechnology-Based Formulations

The preclinical safety assessment of novel nanotechnology-based drug products frequently relies on in vitro assays, especially during the early stages of product development, due to the limited quantities of nanomaterials available for such studies. The majority of immunological tests require donor...

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Bibliographic Details
Main Authors: Edward Cedrone, Barry W. Neun, Jamie Rodriguez, Alison Vermilya, Jeffrey D. Clogston, Scott E. McNeil, Yechezkel Barenholz, Janos Szebeni, Marina A. Dobrovolskaia
Format: Article
Language:English
Published: MDPI AG 2017-12-01
Series:Molecules
Subjects:
nanoparticles
liposomes
hemolysis
platelet aggregation
plasma coagulation
complement activation
leukocyte proliferation
cytokines
safety
immunotoxicity
in vitro
Online Access:https://www.mdpi.com/1420-3049/23/1/12

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https://www.mdpi.com/1420-3049/23/1/12

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