ALPK2 Promotes Cardiogenesis in Zebrafish and Human Pluripotent Stem Cells

Summary: Cardiac development requires coordinated biphasic regulation of the WNT/β-catenin signaling pathway. By intersecting gene expression and loss-of-function siRNA screens we identified Alpha Protein Kinase 2 (ALPK2) as a candidate negative regulator of WNT/β-catenin signaling in cardiogenesis....

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Bibliographic Details
Main Authors: Peter Hofsteen, Aaron Mark Robitaille, Nicholas Strash, Nathan Palpant, Randall T. Moon, Lil Pabon, Charles E. Murry
Format: Article
Language:English
Published: Elsevier 2018-04-01
Series:iScience
Online Access:http://www.sciencedirect.com/science/article/pii/S2589004218300191