Frequent long-range epigenetic silencing of protocadherin gene clusters on chromosome 5q31 in Wilms' tumor.

Frequent long-range epigenetic silencing of protocadherin gene clusters on chromosome 5q31 in Wilms' tumor.

Wilms' tumour (WT) is a pediatric tumor of the kidney that arises via failure of the fetal developmental program. The absence of identifiable mutations in the majority of WTs suggests the frequent involvement of epigenetic aberrations in WT. We therefore conducted a genome-wide analysis of prom...

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Bibliographic Details
Main Authors: Anthony R Dallosso, Anne L Hancock, Marianna Szemes, Kim Moorwood, Laxmi Chilukamarri, Hsin-Hao Tsai, Abby Sarkar, Jonathan Barasch, Raisa Vuononvirta, Chris Jones, Kathy Pritchard-Jones, Brigitte Royer-Pokora, Sean Bong Lee, Ceris Owen, Sally Malik, Yi Feng, Marcus Frank, Andrew Ward, Keith W Brown, Karim Malik
Format: Article
Language:English
Published: Public Library of Science (PLoS) 2009-11-01
Series:PLoS Genetics
Online Access:http://europepmc.org/articles/PMC2776977?pdf=render

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http://europepmc.org/articles/PMC2776977?pdf=render

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