Diverse Brain Myeloid Expression Profiles Reveal Distinct Microglial Activation States and Aspects of Alzheimer’s Disease Not Evident in Mouse Models

Diverse Brain Myeloid Expression Profiles Reveal Distinct Microglial Activation States and Aspects of Alzheimer’s Disease Not Evident in Mouse Models

Microglia, the CNS-resident immune cells, play important roles in disease, but the spectrum of their possible activation states is not well understood. We derived co-regulated gene modules from transcriptional profiles of CNS myeloid cells of diverse mouse models, including new tauopathy model datas...

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Bibliographic Details
Main Authors: Brad A. Friedman, Karpagam Srinivasan, Gai Ayalon, William J. Meilandt, Han Lin, Melanie A. Huntley, Yi Cao, Seung-Hye Lee, Patrick C.G. Haddick, Hai Ngu, Zora Modrusan, Jessica L. Larson, Joshua S. Kaminker, Marcel P. van der Brug, David V. Hansen
Format: Article
Language:English
Published: Elsevier 2018-01-01
Series:Cell Reports
Subjects:
microglia
myeloid
gene expression
RNA-seq
FACS
neuroinflammation
microgliosis
Alzheimer’s disease
neurodegeneration
tauopathy
Online Access:http://www.sciencedirect.com/science/article/pii/S2211124717319034

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http://www.sciencedirect.com/science/article/pii/S2211124717319034

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