Individual Vulnerability to Stress Is Associated With Increased Demand for Intravenous Heroin Self-administration in Rats

Opioid use is a widespread epidemic, and traumatic stress exposure is a critical risk factor in opioid use and relapse. There is a significant gap in our understanding of how stress contributes to heroin use, and there are limited studies investigating individual differences underlying stress reacti...

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Bibliographic Details
Main Authors: Nathaniel P. Stafford, Theodore N. Kazan, Colleen M. Donovan, Erin E. Hart, Robert C. Drugan, Sergios Charntikov
Format: Article
Language:English
Published: Frontiers Media S.A. 2019-06-01
Series:Frontiers in Behavioral Neuroscience
Subjects:
Online Access:https://www.frontiersin.org/article/10.3389/fnbeh.2019.00134/full