Etoricoxib decreases subchondral bone mass and attenuates biomechanical properties at the early stage of osteoarthritis in a mouse model

Etoricoxib decreases subchondral bone mass and attenuates biomechanical properties at the early stage of osteoarthritis in a mouse model

Etoricoxib, a selective Cyclooxygenase-2 (COX-2) inhibitor, is commonly used in osteoarthritis (OA) for pain relief, however, little is known about the effects on subchondral bone. In the current study, OA was induced via destabilization of the medial meniscus (DMM) in C57BL/6 mice. Two days after s...

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Bibliographic Details
Main Authors: Bo Liu, Chenchen Ji, Yijie Shao, Ting Liang, Jiaheng He, Huaye Jiang, Guangdong Chen, Zongping Luo
Format: Article
Language:English
Published: Elsevier 2020-07-01
Series:Biomedicine & Pharmacotherapy
Subjects:
COX-2
Biomechanical properties
Etoricoxib
Microstructures
Osteoarthritis
Subchondral bone
Online Access:http://www.sciencedirect.com/science/article/pii/S075333222030336X

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http://www.sciencedirect.com/science/article/pii/S075333222030336X

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