Model based on GA and DNN for prediction of mRNA-Smad7 expression regulated by miRNAs in breast cancer

Model based on GA and DNN for prediction of mRNA-Smad7 expression regulated by miRNAs in breast cancer

Abstract Background The Smad7 protein is negative regulator of the TGF-β signaling pathway, which is upregulated in patients with breast cancer. miRNAs regulate proteins expressions by arresting or degrading the mRNAs. The purpose of this work is to identify a miRNAs profile that regulates the expre...

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Bibliographic Details
Main Authors: Edgar Manzanarez-Ozuna, Dora-Luz Flores, Everardo Gutiérrez-López, David Cervantes, Patricia Juárez
Format: Article
Language:English
Published: BMC 2018-12-01
Series:Theoretical Biology and Medical Modelling
Subjects:
Deep Neural Networks
Genetic Algorithms
miRNA
regulation
mRNA
Smad7
Online Access:http://link.springer.com/article/10.1186/s12976-018-0095-8

Internet

http://link.springer.com/article/10.1186/s12976-018-0095-8

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