Characterization of Mechanical Allodynia and Skin Innervation in a Mouse Model of Type-2 Diabetes Induced by Cafeteria-Style Diet and Low-Doses of Streptozotocin

Characterization of Mechanical Allodynia and Skin Innervation in a Mouse Model of Type-2 Diabetes Induced by Cafeteria-Style Diet and Low-Doses of Streptozotocin

Background: Painful distal symmetrical polyneuropathy (DPN) is a frequent complication of type-2 diabetes mellitus (T2DM) that commonly presents as neuropathic pain and loss of skin nerve fibers. However, there are limited therapies to effectively treat DPN and many of the current animal models of T...

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Main Authors: Gabriela Castañeda-Corral, Norma B. Velázquez-Salazar, Arisai Martínez-Martínez, Juanita N. Taboada-Serrano, Pablo N. Núñez-Aragón, Laura González-Palomares, Rosa Issel Acosta-González, Vera L. Petricevich, Juan José Acevedo-Fernández, Sergio Montes, Juan Miguel Jiménez-Andrade
Format: Article
Language:English
Published: Frontiers Media S.A. 2021-02-01
Series:Frontiers in Pharmacology
Subjects:
painful distal polyneuropathy
type 2 diabetes mellitus
skin hypersensitivity
mechanical allodynia
skin nerve fibers
cafeteria diet.
Online Access:https://www.frontiersin.org/articles/10.3389/fphar.2020.628438/full

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https://www.frontiersin.org/articles/10.3389/fphar.2020.628438/full

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