Mutation in mouse hei10, an e3 ubiquitin ligase, disrupts meiotic crossing over.

Mutation in mouse hei10, an e3 ubiquitin ligase, disrupts meiotic crossing over.

Crossing over during meiotic prophase I is required for sexual reproduction in mice and contributes to genome-wide genetic diversity. Here we report on the characterization of an N-ethyl-N-nitrosourea-induced, recessive allele called mei4, which causes sterility in both sexes owing to meiotic defect...

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Bibliographic Details
Main Authors: Jeremy O Ward, Laura G Reinholdt, William W Motley, Lisa M Niswander, Dekker C Deacon, Laurie B Griffin, Kristofor K Langlais, Vickie L Backus, Kerry J Schimenti, Marilyn J O'Brien, John J Eppig, John C Schimenti
Format: Article
Language:English
Published: Public Library of Science (PLoS) 2007-08-01
Series:PLoS Genetics
Online Access:https://doi.org/10.1371/journal.pgen.0030139

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https://doi.org/10.1371/journal.pgen.0030139

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