Circular siRNAs for Reducing Off-Target Effects and Enhancing Long-Term Gene Silencing in Cells and Mice

Circular siRNAs for Reducing Off-Target Effects and Enhancing Long-Term Gene Silencing in Cells and Mice

Circular non-coding RNAs are found to play important roles in biology but are still relatively unexplored as a structural motif for chemically regulating gene function. Here, we investigated whether small interfering RNA (siRNA) with a circular structure can circumvent off-target gene silencing, a p...

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Bibliographic Details
Main Authors: Liangliang Zhang, Duanwei Liang, Changmai Chen, Yuan Wang, Gubu Amu, Jiali Yang, Lijia Yu, Ivan J. Dmochowski, Xinjing Tang
Format: Article
Language:English
Published: Elsevier 2018-03-01
Series:Molecular Therapy: Nucleic Acids
Subjects:
oligonucleotides
circular siRNA
off-target effect
gene regulation
RNA digestion
circular oligonucleotides
Online Access:http://www.sciencedirect.com/science/article/pii/S2162253117303062

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http://www.sciencedirect.com/science/article/pii/S2162253117303062

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