The primacy of β1 integrin activation in the metastatic cascade.

The primacy of β1 integrin activation in the metastatic cascade.

After neoplastic cells leave the primary tumor and circulate, they may extravasate from the vasculature and colonize tissues to form metastases. β1 integrins play diverse roles in tumorigenesis and tumor progression, including extravasation. In blood cells, activation of β1 integrins can be regulate...

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Bibliographic Details
Main Authors: Hisashi Kato, Zhongji Liao, John V Mitsios, Huan-You Wang, Elena I Deryugina, Judith A Varner, James P Quigley, Sanford J Shattil
Format: Article
Language:English
Published: Public Library of Science (PLoS) 2012-01-01
Series:PLoS ONE
Online Access:http://europepmc.org/articles/PMC3463578?pdf=render

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http://europepmc.org/articles/PMC3463578?pdf=render

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