Effect of Glycosylation on an Immunodominant Region in the V1V2 Variable Domain of the HIV-1 Envelope gp120 Protein.

Heavy glycosylation of the envelope (Env) surface subunit, gp120, is a key adaptation of HIV-1; however, the precise effects of glycosylation on the folding, conformation and dynamics of this protein are poorly understood. Here we explore the patterns of HIV-1 Env gp120 glycosylation, and particular...

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Bibliographic Details
Main Authors: Jianhui Tian, Cesar A López, Cynthia A Derdeyn, Morris S Jones, Abraham Pinter, Bette Korber, S Gnanakaran
Format: Article
Language:English
Published: Public Library of Science (PLoS) 2016-10-01
Series:PLoS Computational Biology
Online Access:http://europepmc.org/articles/PMC5055340?pdf=render