The Ca2+ transient as a feedback sensor controlling cardiomyocyte ionic conductances in mouse populations

Conductances of ion channels and transporters controlling cardiac excitation may vary in a population of subjects with different cardiac gene expression patterns. However, the amount of variability and its origin are not quantitatively known. We propose a new conceptual approach to predict this vari...

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Bibliographic Details
Main Authors: Colin M Rees, Jun-Hai Yang, Marc Santolini, Aldons J Lusis, James N Weiss, Alain Karma
Format: Article
Language:English
Published: eLife Sciences Publications Ltd 2018-09-01
Series:eLife
Subjects:
Online Access:https://elifesciences.org/articles/36717