Non-invasive characterization of amyotrophic lateral sclerosis in a hTDP-43A315T mouse model: A PET-MR study

Non-invasive characterization of amyotrophic lateral sclerosis in a hTDP-43A315T mouse model: A PET-MR study

Currently TAR DNA binding protein 43 (TDP-43) pathology, underlying Amyotrophic Lateral Sclerosis (ALS), remains poorly understood which hinders both clinical diagnosis and drug discovery efforts. To better comprehend the disease pathophysiology, positron emission tomography (PET) and multi-parametr...

Full description

Bibliographic Details
Main Authors: Akila Weerasekera, Melissa Crabbé, Sandra O. Tomé, Willy Gsell, Diana Sima, Cindy Casteels, Tom Dresselaers, Christophe Deroose, Sabine Van Huffel, Dietmar Rudolf Thal, Philip Van Damme, Uwe Himmelreich
Format: Article
Language:English
Published: Elsevier 2020-01-01
Series:NeuroImage: Clinical
Subjects:
Amyotrophic Lateral Sclerosis
TDP-43
Positron Emission Tomography
Magnetic Resonance Imaging
Magnetic Resonance Spectroscopy
Multimodal Imaging
Online Access:http://www.sciencedirect.com/science/article/pii/S2213158220301649

Internet

http://www.sciencedirect.com/science/article/pii/S2213158220301649

Similar Items