Inhibition of Gastric Tumor Cell Growth Using Seed-targeting LNA as Specific, Long-lasting MicroRNA Inhibitors

Inhibition of Gastric Tumor Cell Growth Using Seed-targeting LNA as Specific, Long-lasting MicroRNA Inhibitors

MicroRNAs regulate eukaryotic gene expression upon pairing onto target mRNAs. This targeting is influenced by the complementarity between the microRNA “seed” sequence at its 5′ end and the seed-matching sequences in the mRNA. Here, we assess the efficiency and specificity of 8-mer locked nucleic aci...

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Bibliographic Details
Main Authors: Cathy Staedel, Christine Varon, Phu Hung Nguyen, Brune Vialet, Lucie Chambonnier, Benoît Rousseau, Isabelle Soubeyran, Serge Evrard, Franck Couillaud, Fabien Darfeuille
Format: Article
Language:English
Published: Elsevier 2015-01-01
Series:Molecular Therapy: Nucleic Acids
Subjects:
gastric adenocarcinoma
LATS2 tumor suppressor
miR-372
miR-373
oncomirs
short LNA oligonucleotides
therapeutic strategy
xenografts in mice
Online Access:http://www.sciencedirect.com/science/article/pii/S2162253116300312

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http://www.sciencedirect.com/science/article/pii/S2162253116300312

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