A systems approach identifies Enhancer of Zeste Homolog 2 (EZH2) as a protective factor in epilepsy.

Complex neurological conditions can give rise to large scale transcriptomic changes that drive disease progression. It is likely that alterations in one or a few transcription factors or cofactors underlie these transcriptomic alterations. Identifying the driving transcription factors/cofactors is a...

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Bibliographic Details
Main Authors: Nadia Khan, Barry Schoenike, Trina Basu, Heidi Grabenstatter, Genesis Rodriguez, Caleb Sindic, Margaret Johnson, Eli Wallace, Rama Maganti, Raymond Dingledine, Avtar Roopra
Format: Article
Language:English
Published: Public Library of Science (PLoS) 2019-01-01
Series:PLoS ONE
Online Access:https://doi.org/10.1371/journal.pone.0226733