Astrocytic endothelin-1 overexpression promotes neural progenitor cells proliferation and differentiation into astrocytes via the Jak2/Stat3 pathway after stroke

Astrocytic endothelin-1 overexpression promotes neural progenitor cells proliferation and differentiation into astrocytes via the Jak2/Stat3 pathway after stroke

Abstract Background Endothelin-1 (ET-1) is synthesized and upregulated in astrocytes under stroke. We previously demonstrated that transgenic mice over-expressing astrocytic ET-1 (GET-1) displayed more severe neurological deficits characterized by a larger infarct after transient middle cerebral art...

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Bibliographic Details
Main Authors: Xiao Cheng, Patrick K. K. Yeung, Ke Zhong, Prince L. M. Zilundu, Lihua Zhou, Sookja K. Chung
Format: Article
Language:English
Published: BMC 2019-11-01
Series:Journal of Neuroinflammation
Subjects:
Endothelin-1
Neural progenitor cells
Astrocyte
Jak2/Stat3
Transient middle cerebral artery occlusion
Online Access:http://link.springer.com/article/10.1186/s12974-019-1597-y

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http://link.springer.com/article/10.1186/s12974-019-1597-y

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