Differentiation-associated reprogramming of the transforming growth factor β receptor pathway establishes the circuitry for epithelial autocrine/paracrine repair.

Differentiation-associated reprogramming of the transforming growth factor β receptor pathway establishes the circuitry for epithelial autocrine/paracrine repair.

Transforming growth factor (TGF) β has diverse and sometimes paradoxical effects on cell proliferation and differentiation, presumably reflecting a fundamental but incompletely-understood role in regulating tissue homeostasis. It is generally considered that downstream activity is modulated at the l...

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Bibliographic Details
Main Authors: Jonathan M Fleming, Saqib Shabir, Claire L Varley, Lisa A Kirkwood, Angela White, Julie Holder, Ludwik K Trejdosiewicz, Jennifer Southgate
Format: Article
Language:English
Published: Public Library of Science (PLoS) 2012-01-01
Series:PLoS ONE
Online Access:http://europepmc.org/articles/PMC3526617?pdf=render

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http://europepmc.org/articles/PMC3526617?pdf=render

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