Upregulated endonuclease Regnase-1 suppresses osteoarthritis by forming a negative feedback loop of catabolic signaling in chondrocytes

Upregulated endonuclease Regnase-1 suppresses osteoarthritis by forming a negative feedback loop of catabolic signaling in chondrocytes

Abstract Background Ribonucleases (RNases) play central roles in the post-transcriptional regulation of mRNA stability. Our preliminary results revealed that the endonuclease Regnase-1 is specifically upregulated in osteoarthritic chondrocytes. We herein explored the possible functions and regulator...

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Bibliographic Details
Main Authors: Jeong-In Yang, Jang-Soo Chun
Format: Article
Language:English
Published: BMC 2021-04-01
Series:Arthritis Research & Therapy
Subjects:
Regnase-1
Chondrocytes
Cartilage
Osteoarthritis
Matrix-degrading enzymes
Online Access:https://doi.org/10.1186/s13075-021-02485-z

Internet

https://doi.org/10.1186/s13075-021-02485-z

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