“Dicing and Splicing” Sphingosine Kinase and Relevance to Cancer

“Dicing and Splicing” Sphingosine Kinase and Relevance to Cancer

Sphingosine kinase (SphK) is a lipid enzyme that maintains cellular lipid homeostasis. Two SphK isozymes, SphK1 and SphK2, are expressed from different chromosomes and several variant isoforms are expressed from each of the isozymes, allowing for the multi-faceted biological diversity of SphK activi...

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Bibliographic Details
Main Authors: Nahal Haddadi, Yiguang Lin, Ann M. Simpson, Najah T. Nassif, Eileen M. McGowan
Format: Article
Language:English
Published: MDPI AG 2017-09-01
Series:International Journal of Molecular Sciences
Subjects:
sphingosine kinase (SphK)
isozymes
variant isoforms
cancer therapy
sphingosine 1 phosphate (S1P)
Online Access:https://www.mdpi.com/1422-0067/18/9/1891

Internet

https://www.mdpi.com/1422-0067/18/9/1891

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