Detection of CHEK2 Ile157Thr Mutation in Cancer Patientsby using Allele Specific PCR

Aims: The checkpoint kinase 2 (CHEK2) was identified as a gene in cell cycle control upon DNA damage. The mutation in this gene is associated with some kinds of cancer including breast and lung tumors. The aim of this study was to investigate, I157T missense mutation of CHEK2 gene by Allele specific...

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Bibliographic Details
Main Authors: Aliarash Anoushirvani, Azam Ahmadi, Mohammad Arjomandzadegan, Reza Aghabozorgi, Mehrana Jafari, Farnaz Mehrabbeygi
Format: Article
Language:English
Published: Amber Publication 2019-02-01
Series:Journal of Research in Medical and Dental Science
Subjects:
ASP
Online Access:https://www.jrmds.in/articles/detection-of-chek2-ile157thr-mutation-in-cancer-patients-by-using-allele-specific-pcr.pdf