Reversal of high fat diet-induced obesity improves glucose tolerance, inflammatory response, β-amyloid accumulation and cognitive decline in the APP/PSEN1 mouse model of Alzheimer's disease

Reversal of high fat diet-induced obesity improves glucose tolerance, inflammatory response, β-amyloid accumulation and cognitive decline in the APP/PSEN1 mouse model of Alzheimer's disease

This study assessed the extent to which high fat diet (HFD)-induced β-amyloid accumulation and cognitive decline in APP/PSEN1 mice are reversible through control of fat intake. Ten months of HFD (60% calories from fat) led to significant deficits in a 2-trial Y maze task, and nest building assay, an...

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Bibliographic Details
Main Authors: Jennifer M. Walker, Shilpy Dixit, Anjelica C. Saulsberry, James M. May, Fiona E. Harrison
Format: Article
Language:English
Published: Elsevier 2017-04-01
Series:Neurobiology of Disease
Subjects:
Obesity
Cognition
Behavior
Inflammatory response, β-amyloid, high fat diet
Online Access:http://www.sciencedirect.com/science/article/pii/S096999611730013X

Internet

http://www.sciencedirect.com/science/article/pii/S096999611730013X

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