Uveal Melanoma Cells Elicit Retinal Pericyte Phenotypical and Biochemical Changes in an in Vitro Model of Coculture

Uveal Melanoma Cells Elicit Retinal Pericyte Phenotypical and Biochemical Changes in an in Vitro Model of Coculture

Vascular pericytes are an important cellular component in the tumor microenvironment, however, their role in supporting cancer invasion is poorly understood. We hypothesized that PDGF-BB could be involved in the transition of human retinal pericytes (HRPC) in cancer-activated fibroblasts (CAF), indu...

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Bibliographic Details
Main Authors: Carmelina Daniela Anfuso, Anna Longo, Alfio Distefano, Angela Maria Amorini, Mario Salmeri, Guido Zanghì, Cesarina Giallongo, Giovanni Giurdanella, Gabriella Lupo
Format: Article
Language:English
Published: MDPI AG 2020-08-01
Series:International Journal of Molecular Sciences
Subjects:
coculture
pericytes
PDGF-B
uveal melanoma
STAT3
Online Access:https://www.mdpi.com/1422-0067/21/15/5557

Internet

https://www.mdpi.com/1422-0067/21/15/5557

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