Effect of FHA and Prn on Bordetella pertussis colonization of mice is dependent on vaccine type and anatomical site.

Effect of FHA and Prn on Bordetella pertussis colonization of mice is dependent on vaccine type and anatomical site.

Bordetella pertussis vaccine escape mutants that lack expression of the pertussis antigen pertactin (Prn) have emerged in vaccinated populations in the last 10-20 years. Additionally, clinical isolates lacking another acellular pertussis (aP) vaccine component, filamentous hemagglutinin (FHA), have...

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Bibliographic Details
Main Authors: Anne Zeddeman, Evi van Schuppen, Kristianne E Kok, Marjolein van Gent, Kees J Heuvelman, Marieke J Bart, Han G J van der Heide, Joshua Gillard, Elles Simonetti, Marc J Eleveld, Fred J H van Opzeeland, Saskia van Selm, Ronald de Groot, Marien I de Jonge, Frits R Mooi, Dimitri A Diavatopoulos
Format: Article
Language:English
Published: Public Library of Science (PLoS) 2020-01-01
Series:PLoS ONE
Online Access:https://doi.org/10.1371/journal.pone.0237394

Internet

https://doi.org/10.1371/journal.pone.0237394

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