CRISPR/Cas9 targeting of GPRC6A suppresses prostate cancer tumorigenesis in a human xenograft model

CRISPR/Cas9 targeting of GPRC6A suppresses prostate cancer tumorigenesis in a human xenograft model

Abstract Background GPRC6A is implicated in the pathogenesis of prostate cancer, but its role remains uncertain because of a purported tolerant gene variant created by substitution of a K..Y polymorphism in the 3rd intracellular loop (IL) that evolved in the majority of humans and replaces the ances...

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Bibliographic Details
Main Authors: Ruisong Ye, Min Pi, John V. Cox, Satoru K. Nishimoto, L. Darryl Quarles
Format: Article
Language:English
Published: BMC 2017-06-01
Series:Journal of Experimental & Clinical Cancer Research
Subjects:
Osteocalcin
GPRC6A
CRISPR/Cas9
Prostate cancer
Online Access:http://link.springer.com/article/10.1186/s13046-017-0561-x

Internet

http://link.springer.com/article/10.1186/s13046-017-0561-x

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