USP1 Regulates Cellular Senescence by Controlling Genomic Integrity

Summary: Oncogene-induced senescence (OIS) is a potent barrier for the transformation of pre-cancerous cells. The molecular pathways involved in the execution of OIS are still incompletely understood, but they include chronic DNA damage signaling and post-translational modifications of key factors....

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Bibliographic Details
Main Authors: Müge Ogrunc, Ricardo Ivan Martinez-Zamudio, Paul Ben Sadoun, Gregory Dore, Helene Schwerer, Philippe Pasero, Jean-Marc Lemaitre, Anne Dejean, Oliver Bischof
Format: Article
Language:English
Published: Elsevier 2016-05-01
Series:Cell Reports
Online Access:http://www.sciencedirect.com/science/article/pii/S2211124716304466