Non-canonical Hedgehog Signaling Pathway in Cancer: Activation of GLI Transcription Factors Beyond Smoothened

Non-canonical Hedgehog Signaling Pathway in Cancer: Activation of GLI Transcription Factors Beyond Smoothened

The Hedgehog-GLI (HH-GLI) pathway is a highly conserved signaling that plays a critical role in controlling cell specification, cell–cell interaction and tissue patterning during embryonic development. Canonical activation of HH-GLI signaling occurs through binding of HH ligands to the twelve-pass t...

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Bibliographic Details
Main Authors: Silvia Pietrobono, Sinforosa Gagliardi, Barbara Stecca
Format: Article
Language:English
Published: Frontiers Media S.A. 2019-06-01
Series:Frontiers in Genetics
Subjects:
Hedgehog
GLI
cancer
non-canonical
oncogene
tumor suppressor
Online Access:https://www.frontiersin.org/article/10.3389/fgene.2019.00556/full

Internet

https://www.frontiersin.org/article/10.3389/fgene.2019.00556/full

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