Use of a Human Artificial Chromosome for Delivering Trophic Factors in a Rodent Model of Amyotrophic Lateral Sclerosis

Use of a Human Artificial Chromosome for Delivering Trophic Factors in a Rodent Model of Amyotrophic Lateral Sclerosis

A human artificial chromosome (HAC) is maintained as an episome within a cell and avoids random integration into the host genome. It can transfer multiple and/or large transgenes along with their regulatory elements thereby resembling native chromosomes. Using this HAC system, we established mesench...

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Bibliographic Details
Main Authors: Yasuhiro Watanabe, Yasuhiro Kazuki, Kanako Kazuki, Mitsutaka Ebiki, Mami Nakanishi, Kazuomi Nakamura, Miho Yoshida Yamakawa, Hiroyuki Hosokawa, Tetsuya Ohbayashi, Mitsuo Oshimura, Kenji Nakashima
Format: Article
Language:English
Published: Elsevier 2015-01-01
Series:Molecular Therapy: Nucleic Acids
Subjects:
amyotrophic lateral sclerosis
human artificial chromosome
mesenchymal stem cells
Online Access:http://www.sciencedirect.com/science/article/pii/S2162253116300385

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http://www.sciencedirect.com/science/article/pii/S2162253116300385

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