Fluorinated Nucleotide Modifications Modulate Allele Selectivity of SNP-Targeting Antisense Oligonucleotides

Fluorinated Nucleotide Modifications Modulate Allele Selectivity of SNP-Targeting Antisense Oligonucleotides

Antisense oligonucleotides (ASOs) have the potential to discriminate between subtle RNA mismatches such as SNPs. Certain mismatches, however, allow ASOs to bind at physiological conditions and result in RNA cleavage mediated by RNase H. We showed that replacing DNA nucleotides in the gap region of a...

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Bibliographic Details
Main Authors: Michael E. Østergaard, Josh Nichols, Timothy A. Dwight, Walt Lima, Michael E. Jung, Eric E. Swayze, Punit P. Seth
Format: Article
Language:English
Published: Elsevier 2017-06-01
Series:Molecular Therapy: Nucleic Acids
Subjects:
antisense oligonucleotide
allele selectivity
fluorinated nucleotides
Huntington’s disease
SNPs
Online Access:http://www.sciencedirect.com/science/article/pii/S2162253117301270

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http://www.sciencedirect.com/science/article/pii/S2162253117301270

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