NADP+ binding to the regulatory subunit of methionine adenosyltransferase II increases intersubunit binding affinity in the hetero-trimer.

NADP+ binding to the regulatory subunit of methionine adenosyltransferase II increases intersubunit binding affinity in the hetero-trimer.

Mammalian methionine adenosyltransferase II (MAT II) is the only hetero-oligomer in this family of enzymes that synthesize S-adenosylmethionine using methionine and ATP as substrates. Binding of regulatory β subunits and catalytic α2 dimers is known to increase the affinity for methionine, although...

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Main Authors: Beatriz González, Francisco Garrido, Rebeca Ortega, Marta Martínez-Júlvez, Ainhoa Revilla-Guarinos, Yolanda Pérez-Pertejo, Adrián Velázquez-Campoy, Julia Sanz-Aparicio, María A Pajares
Format: Article
Language:English
Published: Public Library of Science (PLoS) 2012-01-01
Series:PLoS ONE
Online Access:https://www.ncbi.nlm.nih.gov/pmc/articles/pmid/23189196/?tool=EBI

Internet

https://www.ncbi.nlm.nih.gov/pmc/articles/pmid/23189196/?tool=EBI

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