Type III CRISPR-Cas systems can provide redundancy to counteract viral escape from type I systems

Type III CRISPR-Cas systems can provide redundancy to counteract viral escape from type I systems

CRISPR-Cas-mediated defense utilizes information stored as spacers in CRISPR arrays to defend against genetic invaders. We define the mode of target interference and role in antiviral defense for two CRISPR-Cas systems in Marinomonas mediterranea. One system (type I-F) targets DNA. A second system (...

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Bibliographic Details
Main Authors: Sukrit Silas, Patricia Lucas-Elio, Simon A Jackson, Alejandra Aroca-Crevillén, Loren L Hansen, Peter C Fineran, Andrew Z Fire, Antonio Sánchez-Amat
Format: Article
Language:English
Published: eLife Sciences Publications Ltd 2017-08-01
Series:eLife
Subjects:
Marinomonas mediterranea
CRISPR
phage
bacteria
phage-host arms race
immunity
Online Access:https://elifesciences.org/articles/27601

Internet

https://elifesciences.org/articles/27601

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