Particle size determines the anti-inflammatory effect of wheat bran in a model of fructose over-consumption: Implication of the gut microbiota

• Main Authors: Francesco Suriano, Audrey M. Neyrinck, Joran Verspreet, Marta Olivares, Sophie Leclercq, Tom Van de Wiele, Christophe M. Courtin, Patrice D. Cani, Laure B. Bindels, Nathalie M. Delzenne
• Format: Article
• Language: English
• Published: Elsevier 2018-02-01
• Series: Journal of Functional Foods
• Subjects: Microbiota; Fructose; Inflammation; Wheat bran; Enterobacteriaceae
• Online Access: http://www.sciencedirect.com/science/article/pii/S1756464617307582

We investigated the impact of the particle size of wheat bran on gut dysbiosis and inflammation induced by a fructose overload. Mice received drinking water with or without fructose (30%) and a standard diet supplemented with or without 5% of wheat bran fractions characterized by different average particle sizes (1690 µm versus 150 µm) for 8 weeks. Fructose increased Enterobacteriaceae associated with higher expression of key inflammatory genes in the liver. The two wheat bran fractions differently affected specific gut bacteria known to be involved in the regulation of the gut barrier function and/or inflammatory processes. Moreover, wheat bran with small particle size was the sole fibre that reduced hepatic and systemic inflammatory markers upon high fructose intake. The anti-inflammatory effects of wheat bran may be dependent on their particle size and could be related to the changes in caecal Enterobacteriaceae.