Adjuvanting Allergen Extracts for Sublingual Immunotherapy: Calcitriol Downregulates CXCL8 Production in Primary Sublingual Epithelial Cells

Adjuvanting Allergen Extracts for Sublingual Immunotherapy: Calcitriol Downregulates CXCL8 Production in Primary Sublingual Epithelial Cells

Application of allergens onto the sublingual epithelium is used to desensitize allergic individuals, a treatment known as sublingual immunotherapy. However, the response of sublingual epithelial cells to house dust mite allergen and potential tolerance-promoting adjuvants such as Toll-like receptor...

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Bibliographic Details
Main Authors: Michael P. Pelst, Clara Höbart, Charlotte Wallaeys, Hilde De Rooster, Yannick Gansemans, Filip Van Nieuwerburgh, Bert Devriendt, Eric Cox
Format: Article
Language:English
Published: Frontiers Media S.A. 2020-06-01
Series:Frontiers in Immunology
Subjects:
sublingual
epithelium
Dermatophagoides farinae
Toll-like receptor
calcitriol
CXCL8
Online Access:https://www.frontiersin.org/article/10.3389/fimmu.2020.01033/full

Internet

https://www.frontiersin.org/article/10.3389/fimmu.2020.01033/full

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