CHCHD4 Regulates Intracellular Oxygenation and Perinuclear Distribution of Mitochondria

CHCHD4 Regulates Intracellular Oxygenation and Perinuclear Distribution of Mitochondria

Hypoxia is a characteristic of the tumor microenvironment and is known to contribute to tumor progression and treatment resistance. Hypoxia-inducible factor (HIF) dimeric transcription factors control the cellular response to reduced oxygenation by regulating the expression of genes involved in meta...

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Bibliographic Details
Main Authors: Luke W. Thomas, Oliver Staples, Mark Turmaine, Margaret Ashcroft
Format: Article
Language:English
Published: Frontiers Media S.A. 2017-04-01
Series:Frontiers in Oncology
Subjects:
hypoxia
hypoxia-inducible factor-1α
mitochondria
mitochondrial localization
perinuclear
coiled-coil helix coiled-coil helix domain containing 4
Online Access:https://www.frontiersin.org/article/10.3389/fonc.2017.00071/full

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https://www.frontiersin.org/article/10.3389/fonc.2017.00071/full

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