Glucocorticoid Impaired the Wound Healing Ability of Endothelial Progenitor Cells by Reducing the Expression of CXCR4 in the PGE2 Pathway

Glucocorticoid Impaired the Wound Healing Ability of Endothelial Progenitor Cells by Reducing the Expression of CXCR4 in the PGE2 Pathway

Background: Endothelial progenitor cells (EPCs) can be used to treat ischemic disease in cell-based therapy owing to their neovascularization potential. Glucocorticoids (GCs) have been widely used as strong anti-inflammatory reagents. However, despite their beneficial effects, side effects, such as...

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Bibliographic Details
Main Authors: Erica Carolina, Toshiki Kato, Vuong Cat Khanh, Kana Moriguchi, Toshiharu Yamashita, Kosuke Takeuchi, Hiromi Hamada, Osamu Ohneda
Format: Article
Language:English
Published: Frontiers Media S.A. 2018-09-01
Series:Frontiers in Medicine
Subjects:
endothelial progenitor cells
glucocorticoids
CXCR4
wound healing
prostaglandin E2
HIF2α
Online Access:https://www.frontiersin.org/article/10.3389/fmed.2018.00276/full

Internet

https://www.frontiersin.org/article/10.3389/fmed.2018.00276/full

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